Miraeyeon Fertility Clinic

Miraeyeon OB/GYN and Fertility Clinic drives its name from three traditional Chinese characters 美來緣: meaning Embracing Blessed Relationship. These three simple words symbolize our dedication to faithfully delivering the long waited arrival of precious newborn life through our extensive care and support.

Miraeyeon OB/GYN and Fertility Clinic consists of 3 board-certified female doctors from CHA Medical Center with more than 10 years of medical experience, devoted to whole patient approach in hopes of contributing to well-being of not only patient's body but mind as well. With our vast level of experience and first-rate medical technology , along with superb medical knowledge and ongoing research, we commit to providing every patient with adequate and uncompromising care that goes beyond basic clinical services.

Why Choose MIRAEYEON?

1. Unparalleled Success Rate

As of October 2017, about 65% of our patients have successfully conceived through our fertility treatments. This rate is approximately 15~20% higher than average IVF Success Rates in the United States.

Fertility specialists offer highly effective fertility treatments with wide variety of options including non-surgical fertility treatments, IVF, and other assisted reproductive technologies with proven successful outcomes.

2. Integrated Medical Care

Both emotional health and physical health of our patients are central to our medical care. The treatment process can be both physically and emotionally demanding. When designing each patient's treatment our doctors, nurses, and counselors work in unison to accommodate all our patient's needs and provide individualized patient care system that ensures safety and reduces the occurrence of side effects.

3. Up-to-date Research Facility

We provide the best obstetrical care that focuses on understanding women's physical and psychological needs through solid clinical research. With former research engineer of fertility research department at Gangnam CHA Medical Center, Yu Yeon Lee , as our research manager, we continue to make breakthroughs that are innovational and exclusive to our fertility treatments

4. Top Fertility Doctors

Having technical expertise is important aspect to consider when choosing the right hospital. At Miraeyeon, you can trust our doctors to be perfectly knowledgeable as all three of our female doctors have immense clinical experience with numerous successful surgeries and procedures.

Fertility Diagnosis

Fertility diagnosis (or fertility testing) is recommended when a couple under 35 have not been able to have a baby after a year of trying (with regular, unprotected intercourse), or a woman over 35 has not become pregnant after 6 months of trying.

Physical Exams

Examination of basic physical health of your body and gynecological diagnosis.

Hormonal Examination

Blood tests will be taken during 2nd to 4th day of menstrual cycle to examine the hormones involved in ovulation and pregnancy

Vaginal Ultrasonography

Examines the overall condition of the uterus and ovaries. Depending on the individual need of the test, the examination date may be effected by menstrual cycle due to endometrial changes.

Hystero salpingo contrast sonography (HyCoSy)

HyCoSy is mainly designed for investigating infertility, assessing reproductive status of uterine cavity and fallopian tubes. Since it does not use radiation or iodinated contrast material it is a much safer alternitive to a conventional hysterosalpingogram (HSG). Our clinic offers 4D ultrasonography which is a far more advanced form of HyCoSy, requiring highly experienced specialist. This type of technology is generally only used in research facilities because of its technical requirements, and offers more accurate and solid results while providing safety and reliability.

Ovulation Ultrasound Scan

The examination begins on day 10/12 of menstrual cycle and checks for ovulation status. It proceeds to confirm the growth of the follicles and formation of the teal cells after ovulation.

Semen Analysis (Seminogram)

Evaluates basic characteristics of semen and verifies whether its sperm count, motility, and morphology are within normal range.

Endoscopy

Uterine endoscope is used to directly observe the insides of the uterine cavity when endometrial abnormality is suspected after hysterosalpingogram or vaginal ultrasonography.

Fertility Tests Available by Menstrual cycle

You may visit your doctor at any time during your menstrual cycle during your first visit. However in order to complete basic fertility examinations it will take one whole cycle.

IVF: In vitro fertilization

In vitro fertilization is a procedure in which a mature female oocyte and sperm of the male partner are sampled, fertilized in vitro, cultured for 2 to 5 days, and transplanted into the uterus.

In vitro fertilization is targeted to couples that have been unsuccessful in getting pregnant with other fertility treatments, women who have received tuboplasty in the past but have failed to become pregnant for more than 6 months and women with infertility from immunological cause (cervical mucus containing anti-sperm antibodies), cervical abnormalities, or other unknown causes.

In vitro fertilization (IVF) Process

Induction of Superovulation

An injection called gonadotropin will be injected every day for 8to 10 days from the third day of menstruation to help grow about 5 to 10 follicles. To prevent premature ovulation after follicles have grown to some extent, early ovulation inhibitor (GnRH agonist or antagonist) will be injected. During this procedure, ultrasound and blood tests can be performed to assess the number and size of follicles. If follicles grow to appropriate size, human chrionic gonadotropin (hCG) will be injected 36 hours before the final egg retrieval to aid in the maturation of the oocyte. The types and doses of inducing agent syringes administered during the ovulation induction phase is determined by taking patient's age and ovarian function into consideration. Self-injection is available in case of 피사 injection.

Egg and Semen Collection

After 36 hours of administration of hCG, an oocyte retrieval operation will be carried out. Ultrasound-guided follicular fluid can be aspirated under sleep anesthesia to obtain oocytes in the follicles. The entire procedure will take about 15 ~ 20 minutes. After the procedure, it is recommended for patients to take a rest for about one hour before returning home. On the day of oocyte retrieval, your partner can prepare the semen from the semen collection room by masturbation. Male partner must avoid ejaculating for 2 to 3 days before collection and avoid smoking, drinking and sauna during the preparation period. If your partner has azoospermia, you can also take testicular sperm directly by surgical method.

In vitro fertilization and embryo culture.

Each egg and a sufficient number of sperm that actively move are placed in a culture dish together and are cultured to be fertilized naturally in an incubator with conditions that are similar to that of a human body.

Embryo implantation

The embryo transfer process is the last step in in vitro fertilization and involves implanting the fertilized embryo into the uterus. Vaginal tube is inserted while 질경 is used to clearly see the uterine cervix and 1-3 embryos that have been cultured for 2-5 days is guided through a thin soft tube into the uterus. The number of embryos to be transplanted can be determined by consulting with the clinician as patient's age and condition, embryo status, and previous surgical results will be taken into account. The degree of discomfort during embryo transfer is similar to that of cervical cancer screening so anesthesia is not necessary. Upon completion of procedure we recommend that you take a rest for 30 minutes to 1 hour before returning home and spend next 2-3 days in a stabilized environment. The remaining embryos can be frozen for future use.

Reinforcement of progesterone and confirmation of pregnancy

Once the egg is picked up, an emperor hormone (progesterone) is administered to create an appropriate endometrial environment to conceive. Emperor hormones may be inserted though injections, intravaginal administration, or oral tablets and you may consult with your doctor on the appropriate route of administration.

Assistive procedures in the laboratory

Intracytoplasmic sperm injection (ICSI)

Unlike the general procedure in which an oocyte and sperm are sampled and the natural fertilization is induced in the incubator, in some cases, it is necessary to inject a single sperm of good activity and shape into a single oocyte. This procedure is called intracellular sperm injection. If the sperm status is poor or the fertilization rate is too low after natural fertilization, intracytoplasmic sperm injection will help to increase fertility and fertility.

Laser Assisted Hatching

During the natural pregnancy process, the embryo goes though a process of penetrating through the gelatinous outer membrane, called the zona pellucida, before the implantation into the endometrium. If the zona pellucida is determined to be thick, a small hole is made in the zona pellucida with laser to help the implant before transplanting the embryo.

Blastocyst Culture

In vitro fertilized embryos can be cultured for more than 3 days in the incubator. After 5 days, blastocyst embryos with more than 80 cells, including liquid-cooled river in the center, may develop. By culturing for more than 5 days, you can choose the healthiest embryo prior to transplantation, minimizing the number of transplanted embryos while maintaining the pregnancy rate.

Vitrification

The remaining embryos after in vitro fertilization and fresh embryo transplantation can be frozen and conceived by embryo transfer without induction of ovulation and oocyte retrieval in the next trial. Vitrification uses supersonic cooling technology to freeze an embryo/oocyte by converting them to glassy solid instead of ice, maximizing their survival rate by avoiding the formation of ice crystals. By increasing the embryonic survival rate after thawing, we are able to ensure high pregnancy rate and fertility rate with frozen embryo transplantation as well.

Other assistive procedures

Depending on the patient's condition, embryo glue and intrauterine hCG injection may be supplemented to assist implantation during embryo transfer.

Natural Cycle IVF

Unlike collecting multiple mature oocytes through a procedure of induction of ovulation in a general in vitro fertilization, natural cycle IVF examines a single oocyte that grows to naturally ovulate through the natural menstrual cycle of a woman by ultrasonography. Once confirmed, the egg is collected and fertilized in vitro with sperm from the partner. Pregnancy can be attempted through a natural cycle test-tube procedure for patients who are older or have lowered ovarian function compared to their age, female hormone-sensitive cancer patients, or other patients whose ovulation induction is contraindicated.

Immature Oocyte Test Tube Baby Procedure : In Vitro Maturation (IVM)

It is an in vitro fertilization procedure in which immature oocytes are collected from the ovaries without ovulation inducing agent and are matured and fertilized in vitro. This procedure helps patients with polycystic ovary syndrome, patients with side effects from ovulation induction injections, patients with cancer, and patients with other ovarian stimulation syndromes have a safe pregnancy without complications

• Very few or none superovulation injections are given when menstruation begins
• Special liquid culture is used for 24-48 hours of in vitro maturation
• In vitro fertilization (intracytoplasmic sperm injection: ICSI)
• Embryo implantation

Advantages of the procedure

The risk of developing Ovarian Stimulus Syndrome is reduced by administering no or minimal doses of ovulation-induced injections and the procedure can be performed monthly.

Miraeyeon OB/GYN Clinic offers a variety of in vitro fertilization methods, including general in vitro fertilization (long-term therapy / short-term therapy), natural cycles or hypotonic in vitro fertilization, and immature fertilization in vitro fertilization. Of these, the most appropriate and safe procedure for the patient can be determined by consulting with our doctors taking patient's age, ovarian function, other history, response to previous treatment and results into account.

Preimplantation genetic screening (PGS)

An embryo with a chromosomal abnormality is more likely to become impaired or miscarried. Pre-implantation chromosomal screening tests the chromosomes of the embryos modified by in vitro fertilization and screening for embryos with normal chromosomes to prevent fetal pregnancies with implant failure, spontaneous abortion, and chromosomal abnormalities.

Preimplantation genetic screening (PGS) Candidacy

Preimplantation genetic screening may be able to help elderly women and women who have experienced habitual abortions or have had failures in their previous in vitro fertilization procedure. However, because of the possibility of stomach cancer due to diagnostic limitations and embryo mosaicism, we recommend that you receive prenatal screening through chorionic villus screening or amniocentesis even if pregnancy has been achieved by pre-implantation chromosome screening.

Prenatal Testing

To find risk factors for maternal and fetal pregnancy complications, many tests are routinely performed according to gestational age. Tests performed at the time of preparing for pregnancy or early pregnancy include general blood test, blood test, urine test, rubella test, hepatitis B test, hepatitis C test, sexually transmitted disease test, AIDS test.

Prenatal Care: 1st Trimester Visit

The First Trimester ( ~ 13weeks and 6 days of gestation)

Nuchal Translucency (NT) Screening

The ultrasound exam, called a nuchal translucency, measures the thickness of a space at the back of the fetus's neck. An abnormal measurement means there is an increased risk that the fetus has Down syndrome or another type of aneuploidy. It also is linked to physical defects or the heart, abdominal wall, and skeleton.

NIPT: Non-invasive Prenatal Test (Cell-free DNA Test)

Cell-free DNA is the small amount of DNA that is released from the placenta into a pregnant woman's blood stream. The cell-free DNA in a sample of a woman's blood can be screened for Down syndrome, trisomy 13, trisomy 18. This test can be done starting at 10 weeks of pregnancy. It takes about 1 week to get the results. A positive cell-free DNA test result should be followed by a diagnostics test with amniocentesis or CVS.

Chorionic Villus Sampling (CVS)

CVS is a type of diagnostic test and a procedure to get sample of placental tissue for karyotype. CVS is performed earlier than amniocentesis, between 10 weeks and 13 weeks of pregnancy.

Prenatal Care: 2nd Trimester Visit

Quad Screen test

The quad blood test measures the level of four different substances. The quad test screens for Down syndrome, trisomy 18, and neural tube defects. It is done between 15 weeks and 22 weeks of pregnancy.

The integrated test is integrated test between first- and second-trimester. The resulting outcomes are more accurate than a single test result.

Results of blood screening tests for aneuploidy are reported as the level of risk that the disorder might be present. Diagnostic testing with CVS or amniocentesis that gives a more definite result is an option for all pregnant women.

Amniotic Fluid Analysis

It is a test to diagnose fetal chromosomal abnormalities performed after 15 weeks of pregnancy. Ultrasonically induced fetal amniotic fluid is drawn through the needle and fetal genetic test is performed with amniotic fluid. The likelihood of lethal complications for both mother and fetus is extremely low.

High-resolution Ultrasound Exam (Prenatal Ultrasonography)

In the mid-trimester, ultrasonography can confirm the presence of anatomic malformations of the fetus. It is generally conducted between 18 and 22 weeks of gestation. As the technological development of the ultrasonic equipment has increased the accuracy of test results, importance of the exam has also increased greatly. Depending on the degree of fetal malformations diagnosed by prenatal ultrasonography, appropriate and systematic prenatal care, delivery planning, and consultation and planning for neonatal care should be planned.

Prenatal Care: 3rd Trimester Visit

Antenatal Fetal Surveillance

Tests to evaluate the health of the fetus are conducted from the 32nd to the 34th week of pregnancy, and if necessary, fetus is monitored until the time of delivery. The tests include fetal movement assessment ("kick counts"), Nonstress test (NST), Biophysical Profile (BPP), Modified Biophysical Profile, Contraction Stress Test, and Doppler Ultrasound.

If abnormal fetal growth, inadequate amniotic fluid volume, or other high risk factor is detected through ultrasonography, Doppler examination can be performed to examine placental fetal blood flow and uterine placental blood flow and further tests can be conducted to assess fetal condition if needed.

Well-woman Exam

The examinations will be carried out after consulting symptoms of your condition including menstruation, vaginal bleeding, abnormal vaginal discharge, lower abdominal pain. General physical examination and consultation will take place first, followed by more specialized examination such as earthquake test, infection test, pelvic ultrasonography test and cervical cancer test. The test results will be integrated into counseling for your future health care plans including adult immunizations.

Through ultrasound examination and seismic examination that can safely and anatomically check the body structure in real time, examination of cervical cancer examination, uterine and ovarian disease, pelvic inflammatory test, infection test, examination of breast and thyroid disease are carried out.

For Younger Women

The American Congress of Obstetrics and Gynecology recommends periodic gynecological screenings starting at the age of 13 to 15 with an obstetrician. Obstetrics and gynecology checkups can be somewhat uncomfortable and troublesome because of its exposure of private life. Our medical counselors and nurses are prepared to accommodate you in every detail to minimize the stress during any of our examinations.

Any symptoms in genitals of adolescents and young women often need to be checked to see if they are a temporary symptom during the growth process or an indication to other problems. You can consult and manage your concerns about dysmenorrhea, menstrual irregularities, mood disorders due to menstrual cycles, acne, weight, sex-related symptoms, contraception, and sexually transmitted diseases.

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